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Secukinumab gets EC approval for treating hidradenitis suppurativa
Cosentyx® (secukinumab) became the only new biologic approved in the last decade for this condition. It provided rapid symptom relief by week 4, with increasing response rates for up to a year. The safety profile of the drug was already established across other indications. The drug is also used fot treating plaque psoriasis, spondylitis, spondyloarthritis, and arthritis.
Not taking COVID-19 vaccines tied to avoidable hospitalizations
COVID-19 patients who were eligible for vaccination but did not take them had a 10 times higher hospitalization risk than those who received two doses. They also had 21 times higher risk than those who took a booster or a third dose. The study estimated that costs of $101.46 million and $110.24 million could be avoided with full and booster vaccination, respectively.
FDA warns against compounding semaglutide
The agency received reports of adverse events after some patients used compounded semaglutide. Thus, FDA warned against using compounded drugs when an approved drug is available. Patients and physicians are urged to understand that such products may contain salt forms and FDA does not review the safety and effectiveness of compounded versions of drugs.
Exercise could improve pain tolerance
Researchers studied self-reported physical activity levels and pain tolerance of people twice in eight years. They found that more active lifestyles were associated with more pain tolerance. Also, the pain endurance increased as more people reported exercising over the study period. These findings suggest exercise could become a non-pharmacological way to prevent chronic pain.
Things to know about hand, foot and mouth disease
It starts with cold-like symptoms leading to mouth sores and skin rashes lasting almost 10 days. Patients are most contagious in the first few days, but the virus can pass through stools for weeks. Although it is common in kids aged under 5 years, even caregivers can get infected and sick. People can catch it multiple times as it is caused by multiple viruses.
New treatment for REM sleep behaviour disorder
This disorder is caused due to neurodegeneration from the accumulation of tau protein in the brain. A recent study found that dual orexin receptor antagonists can benefit patients with this condition. These drugs reduced the time to fall asleep and improved the duration and quality of sleep in mouse models, raising hopes for testing these FDA-approved drugs in humans.
Paper that surveyed parents of kids with gender dysphoria retracted
The article will be retracted due to a lack of informed consent, as per the author. The paper has the findings from the survey involving parents who were contacted through a website. It reported that parents felt pressure from the clinicians to affirm the new gender and transition of their kids. It attracted criticism soon after its publication in Springer Nature.
France to launch a bird flu vaccination program
The decision from France's farm ministry came after a series of tests on ducks revealed satisfactory vaccine effectiveness and reasonable control over virus transmission. France has already ordered 80 million vaccines and plans to launch the program by autumn 2023. The bird flu virus has caused the culling of 200 million birds in the last 18 months.
Stress-related psychiatric disorders tied to cardiac arrest out of hospital
Patients suffering from long-term stress-related disorders like post-traumatic stress disorder or anxiety are at a higher risk of developing out-of-hospital cardiac arrest, as per a study. This association was seen in women and men and was independent of the existence of cardiovascular disease. These findings warrant raising awareness among such patients while treating them.
What are the side effects of sucking in your stomach?
Stomach gripping or sucking it in repeatedly to look thinner can cause several health issues. It can lead to breathing issues due to the contraction of the diaphragm in the opposite direction, neck and back pain as the gripping affects the core muscles, and pelvic floor problems as it weakens soft tissues from a constant stretched state, ultimately leading to urine leakage.