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A bone-safe dose of steroids for musculoskeletal diseases is hard to find
Researchers found that patients treated with more than 2.5 mg daily glucocorticoid dose suffered an irreversible loss in bone mineral density irrespective of osteoporosis treatment. Patients on a 2.5 mg dose of glucocorticoids plus bisphosphonates therapy gained bone mineral density. In contrast, those receiving a 5 mg dose plus bisphosphonate therapy lost bone mineral density.
Healio
Researchers propose the first classification standards for CNO/CRMO
The findings that are in favour of CNO/CRMO are intermittent bone pain, swelling in the upper body, presence of symmetrical lesions, bone pain in the upper body, and presence of fibrosis or adaptive immune cells in the biopsy. On the other hand, signs of infection, fever, abnormal CT/X-ray/MRI, cancer in a biopsy, and pain resolved with antibiotics.
Local Today
NSAIDs may reduce fertility in females with spondyloarthritis
Women who are of older age suffering from spondyloarthritis and used NSAIDS during their preconception period took longer to conceive, according to a study. These findings describe the harmful effects of NSAIDs on fertility in females with spondyloarthritis. The findings also suggest considering the discontinuation of NSAIDs in women with difficulties conceiving.
Healio
Subclinical hyperthyroidism tied to fracture risk
People with subclinical hyperthyroidism were associated with a 34% increased risk of fractures compared to patients with euthyroidism, as per a study. The fracture risk was higher among patients with thyrotropin levels below 0.56 mIU/L. These findings suggest the need for aggressive screening and monitoring for bone mineral disease in people with subclinical hyperthyroidism.
Twitter @JAMANetworkOpen
TNF biologics could raise the risk of multiple sclerosis
Research from Canada has linked the use of anti-TNFα biologics, drugs for treating immune-related conditions, to the development of multiple sclerosis. People with rheumatoid arthritis taking these drugs had a 105% higher risk of MS compared to patients who did not take these drugs. These findings could help patients and physicians make informed decisions.
BioSpace
ACR's guidance on integrative interventions for rheumatoid arthritis
It addresses the use of rehabilitation, exercise, diet and other interventions in combination with DMARDs specifically for RA. The panel strongly recommends consistent engagement in exercise and conditionally recommends aerobic, aquatic, and resistance exercises. It advised against diets other than Mediterranean style and supplements, electro- and chiropractic therapies.
American College of Rheumatology
Giving birth could cause permanent changes in the mother's bones
A study on rhesus monkeys involving the evaluation of bones revealed that monkeys that had given birth had lower levels of phosphorous, calcium, and magnesium in their bones than monkeys that did not give birth. Also, magnesium levels were different between these groups and correlated with breastfeeding. These findings suggest reproduction could affect bone composition.
Twitter @GenesisTrustUK
Trigger finger may indicate diabetes, says a new study
The rate of trigger finger, caused by the thickening of tendons, in people with diabetes was 10% to 15% than 1% to 1.5% in the general population. Moreover, higher blood glucose levels were linked to higher chances of trigger finger in patients with type 1 or type 2 diabetes. Men with unregulated HbA1C had a 5 times higher risk than men with controlled HbA1C.
News Break
US FDA expands upadacitinib's indications
RINVOQ® (upadacitinib 15 mg, once daily) became the only oral JAK inhibitor for treating active non-radiographic axial spondyloarthritis in adults. It is the sixth indication of the drug. It has been approved for rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, active ankylosing spondylitis, and eczema. It is a selective JAK inhibitor developed by AbbVie.
AbbVie
NICE guidelines on diagnosing and managing osteoarthritis
It says that osteoarthritis can be diagnosed clinically without imaging in people aged above 45 years, people who have joint pain, morning joint-related stiffness, or that lasting more than 30 minutes. It stresses therapeutic exercise, weight management, manual therapy, acupuncture, electrotherapy, other devices, topical, oral, and transdermal medicines, and injections.
National Institute for Health and Care Excellence
