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Flu vaccine could protect against Alzheimer's disease
People who received a minimum of one influenza vaccine dose were 40% less likely to develop Alzheimer's disease than unvaccinated people, as per a study. The protective effect increased with the increase in the number of annual flu vaccines a person received, indicating that people who consistently received a yearly flu vaccine had the lowest risk of Alzheimer's disease.
University of Texas Health Science Center at Houston
A reduction in brain size could be seen in people with anorexia
Individuals with anorexia showed a notable decrease in the subcortical volume, cortical thickness, and cortical surface areas, as per a study. The reduction ranges between 2 and 4 times more than the abnormalities in brain shape and size of the people with mental illnesses. However, the reduction of brain structure was less severe in people who recovered from anorexia.
Early use of tofersen could slow the disease progression in patients with ALS
Early initiation of tofersen showed slow progression of disability and improvements in muscle strength, lung function and quality of life in patients with a mutation in the SOD1 gene compared with a 6-month delay in treatment, as per a study. Also, the early use of tofersen was accompanied by a sustained and pronounced decrease in the neurofilament light chain.
ALS News Today
Atogepant shows good response rates as prophylactic migraine therapy
Oral atogepant treatment showed response as early as four weeks and enhanced over time, in adults with migraine, as per a study. Mean monthly migraine days (MMDs) was reduced by 50% with the atogepant treatment for 12 weeks. Higher doses of the drug produced the greatest rates of response. Its response rates were consistent with the other migraine treatments
Individuals with developmental dyslexia could exhibit complementary cognition
People with developmental dyslexia possess some strengths linked to exploring the unknown, contributing to the survival and adaptation of the human species, as per a study. The areas of difficulty in people with dyslexia were due to the cognitive trade-off between exploiting knowledge and exploring new information, which enhances their discovery and creativity abilities.
University of Cambridge
Incomplete imaging of patients with mini-stroke may put them at stroke risk
Only 60% of patients diagnosed with a transient ischemic attack (TIA) received complete imaging within 48 hours. About 29.9% of patients discharged from the ED with incomplete TIA imaging. Shortage of primary care providers and outpatient imaging centres and less access to imaging services are causes of delayed, incomplete, and never performed TIA imaging after ED discharge.
IVIg therapy during pregnancy might not increase long-term NDI risk in children
Children from mothers who received intravenous immunoglobulin (IVIg) during pregnancy for FNAIT had no severe neurodevelopmental impairment (NDI), as per a study. However, 14% of the children after antenatal IVIg treatment had mild to moderate NDI. These findings suggest normal cognitive and behavioural development could be expected in kids born after antenatal IVIg treatment.
Hearing loss could increase the risk of dementia
A geriatric medicine expert said that as age progresses, hearing loss makes some people withdraw from peer conversations and reduces participation in various activities, making the people less engaged and social. This less brain stimulation could cause growth decline of different neuronal pathways responsible for memory function resulting in dementia.
Vidofludimus calcium could suppress the MRI lesions in patients with RRMS
Patients with RRMS who received 45 mg and 30 mg of vidofludimus calcium once a day showed a decrease in the CUA MRI lesions' cumulative number up to week 24 by 62% and 70%, respectively, compared to those in placebo, as per phase 2 EMPhASIS trial. Also, vidofludimus calcium was well tolerated, and its safety profile was comparable to that in the placebo groups.
Frontostriatal mechanisms could cause aggression towards outgroup members
People showed an aggressive tendency to harm other people in opposing groups due to increased activity in the brain's reward network, as per a study. This aggression was positively associated with increased neuronal activity in the dorsal and rostral medial prefrontal cortex, ventral striatum, and the nucleus accumbens while deciding the magnitude of aggression.
Virginia Commonwealth University