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Allopurinol could increase the risk of chronic kidney disease

Time : 23rd of June 2022 09:03:58 AM Physician/Medicine,Pharma News,Nephrology

Uric acid-lowering therapy with allopurinol was associated with an increased risk of new-onset chronic kidney disease in patients with 8 mg/dL or less serum uric acid levels, as per a study. Allopurinol could induce acute interstitial nephritis, thereby increasing the risk of albuminuria and reducing eGFR to less than 60 mL/min/1.73 m2 by 7% and 24%, respectively.
  Renal & Urology News

Pediatricians transplant kidneys without using immune-suppressing drugs

Time : 20th of June 2022 01:18:45 PM Physician/Medicine,Paediatrics,Nephrology,General Surgery

The team enabled the children with the immune disorders to receive a new immune system and matched kidney from a parent using a dual immune/solid organ transplant (DISOT). This innovation removes the possibility of immune rejection of the transplanted kidney in the recipient and safely frees the patient from lifelong immunosuppression after a kidney transplant.
  Stanford University Medical Center

Nighttime masked uncontrolled hypertension linked to poor CKD outcomes

Time : 16th of June 2022 12:59:19 PM Physician/Medicine,Nephrology,Cardiology

Masked uncontrolled hypertension that occurs overnight is widespread in chronic kidney disease (CKD) patients and is linked to left ventricular hypertrophy (LVH) and reduced renal function, as per a study. The findings led to a need for ambulatory blood pressure monitoring (ABPM) in hypertensive and CKD patients, even in those with well-controlled office hypertension.
  American College of Cardiology

Adjuvant everolimus appears favourable in very high-risk kidney cancer

Time : 13th of June 2022 12:30:39 PM Oncology,Nephrology

Adjuvant everolimus improved recurrence-free survival (RFS) in patients with totally resected renal cell carcinoma who have a high risk of disease recurrence. The everolimus arm had a 5-year RFS rate of 67%, while the placebo arm had a rate of 63%. The effect of everolimus on RFS was more prominent in the very high-risk group than in the intermediate high-risk group.
  Renal & Urology News

Methylprednisolone could slow the disease progression in patients with IgAN

Time : 10th of June 2022 02:03:06 PM Physician/Medicine,Nephrology

Patients who received methylprednisolone had a 47% reduced risk of kidney failure, lowering eGFR or death than those who received a placebo, according to researchers. Also, methylprednisolone treatment showed a 4.8% decline in the composite outcomes. The annual rate of eGFR decrease in methylprednisolone and placebo groups was 2.50 and 4.97 mL/min/1.73m2, respectively.

  Renal & Urology News

Potassium chloride supplementation may raise hyperkalemia risk in CKD patients

Time : 8th of June 2022 03:23:55 PM Nephrology

Patients with CKD who take KCl supplements had an increase in urinary potassium excretion, plasma aldosterone, and plasma potassium but did not improve urinary sodium excretion, BP, plasma renin, and albuminuria. In addition, there is an increase in plasma chloride and a decrease in plasma bicarbonate and urine pH, but it did not show any effect on urinary ammonium excretion.

  Renal & Urology News

SGLT2 inhibitors could increase the uric acid excretion via urine

Time : 3rd of June 2022 11:21:17 AM Physician/Medicine,Pharma News,Nephrology,Endocrinology & Diabetes

Dapagliflozin, an SGLT2 inhibitor, decreased the serum uric acid concentration by accentuating uric acid excretion through urine, which is associated with sodium and glucose urinary excretion, as per a study. Dapagliflozin reduced plasma uric acid concentration by 0.8 mg/dL, 1.0 mg/dL, and 0.8 mg/dL during fasting, hyperinsulinemia, and hyperglycemia, respectively.

  Renal & Urology News

Scientists identify a new kidney and liver disease

Time : 30th of May 2022 03:56:26 PM Physician/Medicine,Nursing,Nephrology,General Surgery,Gastroenterology,Diagnostics & Pathology

An inherited condition called TULP-3 related ciliopathy, which causes liver and kidney disease in adults and children, was established. A review of clinical symptoms and collection of urine samples, genetic sequencing and liver biopsies of 15 patients with the new disease showed that half of them had liver or kidney transplants, and their conditions deteriorated.

  Newcastle University

Pig-to-human kidney xenotransplantation shows promising results

Time : 27th of May 2022 12:56:02 PM Physician/Medicine,Nephrology

Kidney xenografts from pigs showed that the patients produced urine immediately after reperfusion, according to two cases. Also, an increase in estimated glomerular filtration rate and a decrease in serum creatinine levels over 54 hours were observed in both recipients. Also, no signs of antibody-mediated or hyperacute rejections in biopsy samples were found.

  Renal & Urology News

Coffee consumption could benefit patients with AKI

Time : 26th of May 2022 05:01:33 PM Nutrition & Fitness,Nephrology

Patients who consumed higher amounts of coffee had a lower risk of incident acute kidney injury (AKI), as per a study. Chronic coffee consumption could be a good opportunity for cardiorenal protection via diet, especially in preventing AKI procedures or hospitalisations. However, extensive studies are needed to evaluate the various effects of coffee on renal function.

  Twitter @CareDx