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China approves sugemalimab to treat unresectable NSCLC
CStone Pharmaceuticals said that the NMPA of China approved the first anti-PD-1/PD-L1 monoclonal antibody, sugemalimab, for treating patients with unresectable non-small cell lung cancer (NSCLC) stage III whose disease did not progress after platinum-based chemoradiotherapy. Sugemalimab increased the overall survival rate in patients with NSCLC.
Atherosclerosis and diabetes together cause more deaths among Asian Indians
Concurrent diabetes and atherosclerosis was the most common cause of death among US Asian Indians compared to non-Asian Indians, as per a study. The effect of these diseases on mortality was highest among Asian Indian women aged over 60 years compared to non-Asian Indian women. These findings suggest targeted health strategies among Asian Indians to prevent both diseases.
Electrical stimulation plus sound could decrease chronic pain
Scientists developed a new technique by combining transcutaneous electrical nerve stimulation with the sound that activates the somatosensory cortex resulting in significant relief from chronic pain and sensory disorders in animal models. This technique is non-invasive, simple, and cost-effective compared to many conventional treatments for chronic pain.
University of Minnesota
A bioengineered cornea could restore vision in visually impaired people
Researchers developed a bioengineered implant that restored vision in 20 individuals with the severely diseased cornea, mostly all of whom were blind before receiving the implant. This implant resembles the human cornea and is made from collagen protein extracted from the pigs' skin. The bioengineered implant can be preserved for up to a couple of years.
Immune profiling reveals pathological features of long Covid
Patients with long Covid frequently reported post-exertional malaise, fatigue, and cognitive and autonomic dysfunctions, as per a study. Decreased cortisol levels, elevated humoral responses against SARS-CoV-2, abnormal lymphocyte and myeloid populations, and increased antibody responses against EBV are the key pathological changes found in patients with long Covid.
Isocyanates in wound dressings and diabetic devices cause allergic dermatitis
Eight of nineteen patients with suspected allergic contact dermatitis from polyurethane reacted significantly to isocyanates and related amines present in wound dressings and diabetes devices, as per a study. This study suggests patch tests with isocyanates in patients with suspected allergic contact dermatitis before using polyurethane-containing devices.
Huanan market was the COVID-19 pandemic epicentre, not the virology lab
The emergence of the SARS-CoV-2 occurred through the live mammals and wildlife trade in the Huanan seafood market, Wuhan, China, indicating that the Huanan wildlife market was the epicentre for the COVID-19 pandemic, as per research. From its origin in the market, the virus spread rapidly to the whole world but not from the Wuhan Institute of Virology.
UK approves Moderna's bivalent COVID-19 vaccine as booster shots
The MHRA approved the updated Moderna's COVID-19 vaccine which offers better protection against the Omicron variant. This bivalent vaccine can stimulate immune responses against two antigens, namely, the original wild SARS-CoV-2 variant and the BA.1, the first sublineage of the Omicron variant, which showed significant resistance to the existing vaccines.
A woman with monkeypox used TikTok to fight disease misinformation
The 20-year-old woman stated that she didn’t contract the virus by sex but believed that she contracted the virus while handling dirty money at her job at a gas station. She presented to a hospital after noticing blisters on her face and tested positive for the monkeypox virus. She was isolated for two weeks and reported itching, joint pain, headache and fainting.
New York Post
Scientists developed a long-acting injectable drug delivery system for TB
The long-acting injectable formulation of rifabutin, an anti-tuberculosis drug, is also affordable. It would help ease the burden of tuberculosis (TB) on low-income people. The new drug delivery system of rifabutin prevented the infection in the TB-exposed mice. A single injection cleared the lung infection and other tissue infections in the mice with TB.
University of North Carolina at Chapel Hill School of Medicine